Fis1^tm1.1Dcc
Targeted Allele Detail

Summary

• Symbol: Fis1^tm1.1Dcc
• Name: fission, mitochondrial 1; targeted mutation 1.1, David C Chan
• MGI ID: MGI:6755478
• Synonyms: Fis1^delta
• Gene: Fis1 Location: Chr5:136982129-136995088 bp, + strand Genetic Position: Chr5, 76.06 cM, cytoband G1
• Alliance: Fis1^tm1.1Dcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309044
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The targeting construct flanked exon 2 with loxP sites. Cre-mediated recombination removed exon 2. (J:309044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fis1 Mutation: 47 strains or lines available

References

• Original: J:309044 Varuzhanyan G, et al., Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation. Development. 2021 Aug 15;148(16):dev199686
• All: 1 reference(s)