Prlh^em1(cre)Mgmj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prlh^em1(cre)Mgmj
• Name: prolactin releasing hormone; endonuclease-mediated mutation 1, Martin G Myers, Jr
• MGI ID: MGI:6757218
• Synonyms: Prlh^cre
• Gene: Prlh Location: Chr1:90880830-90881749 bp, + strand Genetic Position: Chr1, 45.81 cM
• Alliance: Prlh^em1(cre)Mgmj page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL)F2

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Prlh^em1(cre)Mgmj expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prlh (MGI:3644668)

• CRISPR/cas9 genome editing is used to insert an IRES and Cre recombinase at the stop codon. (J:309169)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prlh (mouse) Summary of all recombinase alleles driven by Prlh. Comparative matrix view of recombinase activities Alliance mouse Prlh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prlh Mutation: 7 strains or lines available

References

• Original: J:309169 Cheng W, et al., NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 Aug 30;12(1):5175
• All: 1 reference(s)