Aurkb^{tm1.1(cre/ERT2)Deli}
Targeted Allele Detail

Summary

• Symbol: Aurkb^{tm1.1(cre/ERT2)Deli}
• Name: aurora kinase B; targeted mutation 1.1, Deqiang Li
• MGI ID: MGI:6758108
• Synonyms: Aurkb^{ER Cre}
• Gene: Aurkb Location: Chr11:68936477-68942490 bp, + strand Genetic Position: Chr11, 42.32 cM
• Alliance: Aurkb^{tm1.1(cre/ERT2)Deli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309046
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Mutation: Insertion
• Aurkb^{tm1.1(cre/ERT2)Deli} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aurkb (MGI:107168)

• Mutation details: The allele was generated by homologous recombination in embryonic stem cells targeting a Cre-Ert2-V2A-tdTomato-Frt-PGK-neo-Frt cassette into the start codon of the Aurkb locus. The PGK-Neo cassette was removed by breeding the initial progeny to mice expressing Flpe recombinase. (J:309046)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aurkb (mouse) Summary of all recombinase alleles driven by Aurkb. Comparative matrix view of recombinase activities Alliance mouse Aurkb gene page

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aurkb Mutation: 23 strains or lines available

References

• Original: J:309046 Jang J, et al., An Engineered Mouse to Identify Proliferating Cells and Their Derivatives. Front Cell Dev Biol. 2020;8:388
• All: 1 reference(s)