Trpc5^{tm1.1(cre)Dbru}
Targeted Allele Detail

Summary

• Symbol: Trpc5^{tm1.1(cre)Dbru}
• Name: transient receptor potential cation channel, subfamily C, member 5; targeted mutation 1.1, Dieter Bruns
• MGI ID: MGI:6758141
• Synonyms: TRPC5-IC, TRPC5-IRES-Cre
• Gene: Trpc5 Location: ChrX:143164667-143471176 bp, - strand Genetic Position: ChrX, 65.49 cM, cytoband F2
• Alliance: Trpc5^{tm1.1(cre)Dbru} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287788
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Trpc5^{tm1.1(cre)Dbru} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trpc5 (MGI:109524)

• Mutation details: The targeting construct inserted an IRES-Cre-pgk promoterdriven Flp recombination target (FRT)neomycin (neo)FRT cassette into final exon 11 of the Trpc5 gene by homologous recombination in ES cells. The FRT flanked neo selection cassette was removed by FLP-deleter mice. (J:287788)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trpc5 (mouse) Summary of all recombinase alleles driven by Trpc5. Comparative matrix view of recombinase activities Alliance mouse Trpc5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpc5 Mutation: 21 strains or lines available

References

• Original: J:287788 Schwarz Y, et al., TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. PLoS Biol. 2019 Sep;17(9):e3000445
• All: 2 reference(s)