Cerkl^em1Gmar
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cerkl^em1Gmar
• Name: ceramide kinase-like; endonuclease-mediated mutation 1, Gemma Marfany
• MGI ID: MGI:6758642
• Synonyms: Cerkl^KO
• Gene: Cerkl Location: Chr2:79162835-79259332 bp, - strand Genetic Position: Chr2, 47.43 cM
• Alliance: Cerkl^em1Gmar page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted approximately 97 kb with full deletion from the proximal promoter up to exon 13 (does not affect exon 13). This line represents mouse 2 which was chosen as the founder for the colony. (J:292626)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cerkl Mutation: 29 strains or lines available

References

• Original: J:292626 Domenech EB, et al., A New Cerkl Mouse Model Generated by CRISPR-Cas9 Shows Progressive Retinal Degeneration and Altered Morphological and Electrophysiological Phenotype. Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):14
• All: 3 reference(s)