Tbx21^{tm1.1(cre/ERT2)Ayr}
Targeted Allele Detail

Summary

• Symbol: Tbx21^{tm1.1(cre/ERT2)Ayr}
• Name: T-box 21; targeted mutation 1.1, Alexander Y Rudensky
• MGI ID: MGI:6758779
• Synonyms: Tbx21^{tdTomato-T2A-creERT2}
• Gene: Tbx21 Location: Chr11:96988897-97006157 bp, - strand Genetic Position: Chr11, 60.95 cM, cytoband D
• Alliance: Tbx21^{tm1.1(cre/ERT2)Ayr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248943
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tbx21^{tm1.1(cre/ERT2)Ayr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx21 (MGI:1888984)

• Mutation details: The IRES-tdTomato-T2A-CreERT2-frt-NEO-BGHpA-frt sequence was inserted into the Tbx21 3' UTR by homologous recombination in the ES cells. Mice were bred to FLPeR mice to excise the NEO cassette. (J:248943)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx21 (mouse) Summary of all recombinase alleles driven by Tbx21. Comparative matrix view of recombinase activities Alliance mouse Tbx21 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx21 Mutation: 39 strains or lines available

References

• Original: J:248943 Levine AG, et al., Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Jun 15;546(7658):421-425
• All: 3 reference(s)