Ghsr^{tm1.1(cre)Jmz}
Targeted Allele Detail

Summary

• Symbol: Ghsr^{tm1.1(cre)Jmz}
• Name: growth hormone secretagogue receptor; targeted mutation 1.1, Jeffrey M Zigman
• MGI ID: MGI:6759033
• Synonyms: Ghsr-IRES-Cre
• Gene: Ghsr Location: Chr3:27425500-27432159 bp, + strand Genetic Position: Chr3, 10.86 cM
• Alliance: Ghsr^{tm1.1(cre)Jmz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309625
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ghsr^{tm1.1(cre)Jmz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ghsr (MGI:2441906)

• Mutation details: An IRES-Cre-FRT-neo-FRT cassette was inserted into three base pairs (bp) downstream of the mouse Ghsr STOP codon. An frt-flanked neomycin selection cassette was removed via flpe mediated recombination. (J:309625)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ghsr (mouse) Summary of all recombinase alleles driven by Ghsr. Comparative matrix view of recombinase activities Alliance mouse Ghsr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghsr Mutation: 27 strains or lines available

References

• Original: J:309625 Mani BK, et al., The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting. Mol Metab. 2017 Aug;6(8):882-896
• All: 5 reference(s)