Tg(Asic1-cre)1Cibms
Transgene Detail

Summary

• Symbol: Tg(Asic1-cre)1Cibms
• Name: transgene insertion 1, Chih-Cheng Chen
• MGI ID: MGI:6759763
• Synonyms: Asic1b^Cre, ASIC1b-Cre
• Transgene: Tg(Asic1-cre)1Cibms Location: unknown
• Alliance: Tg(Asic1-cre)1Cibms page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Asic1-cre)1Cibms expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Asic1 (MGI:1194915)

• Mutation details: The transgene consists of a ~4.5-kb mouse genomic DNA fragment containing the promoter upstream of the ATG translation start codon of a splicing variant of Asic1, ASIC1b to drive the Cre recombinase expression. The whole ASIC1b-CreDNA cassette was flanked by the chicken hypersensitive site 4 (HS4) insulator. Five founder mice were retained for copy number verification and two founder lines bearing a minimum copy transgene were screened. One of the five founder mice showing expression of Cre only in the trigeminal ganglia and DRG but not the brain was used for the study. (J:309655)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Asic1 (mouse) Summary of all recombinase alleles driven by Asic1. Comparative matrix view of recombinase activities Alliance mouse Asic1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:309655 Chang CT, et al., Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain. Front Neurosci. 2019;13:1247
• All: 1 reference(s)