Cacna1h^{tm2.1(cre)Glwn}
Targeted Allele Detail

Summary

• Symbol: Cacna1h^{tm2.1(cre)Glwn}
• Name: calcium channel, voltage-dependent, T type, alpha 1H subunit; targeted mutation 2.1, Gary R Lewin
• MGI ID: MGI:6759808
• Synonyms: Cav3.2^Cre
• Gene: Cacna1h Location: Chr17:25593259-25652759 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Cacna1h^{tm2.1(cre)Glwn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• Cacna1h^{tm2.1(cre)Glwn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cacna1h (MGI:1928842)

• Mutation details: Targeting vectors to insert cre expression cassette after the start codon of the Cacna1h (Cav3.2) gene located at the second exon was used to generate the allele by homologous recombination in ES cells. The insertion of the cre cassettes produces a null mutation of the Cacna1h gene. The neo cassette was removed by flpe recombinase. (J:309445)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cacna1h (mouse) Summary of all recombinase alleles driven by Cacna1h. Comparative matrix view of recombinase activities Alliance mouse Cacna1h gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1h Mutation: 98 strains or lines available

References

• Original: J:309445 Bernal Sierra YA, et al., Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System. Front Mol Neurosci. 2017;10:70
• All: 1 reference(s)