Tg(Zic2-cre/ERT2)1453Kln
Transgene Detail

Summary

• Symbol: Tg(Zic2-cre/ERT2)1453Kln
• Name: transgene insertion 1453, Rudiger Klein
• MGI ID: MGI:6760601
• Synonyms: Zic2cre^ER
• Transgene: Tg(Zic2-cre/ERT2)1453Kln Location: unknown
• Alliance: Tg(Zic2-cre/ERT2)1453Kln page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Zic2-cre/ERT2)1453Kln expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Zic2 (MGI:106679)

• Mutation details: The transgene was generated by a bacterial recombineering technique to insert a cre/ERT2 expression cassette containing the polyadenylation site (polyA) from the SV40 early region into the exon 1 of the mouse Zic2 gene of a BAC clone RP23-158G6 (CHORI). Two transgenic founder lines were selected and established. Line 1453 shows specific cre activity in the spinal cord. (J:284540)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Zic2 (mouse) Summary of all recombinase alleles driven by Zic2. Comparative matrix view of recombinase activities Alliance mouse Zic2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:284540 Paixao S, et al., Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron. 2019 Nov 20;104(4):749-764.e6
• All: 1 reference(s)