Tg(Zic2-cre/ERT2)1463Kln
Transgene Detail

Summary

• Symbol: Tg(Zic2-cre/ERT2)1463Kln
• Name: transgene insertion 1463, Rudiger Klein
• MGI ID: MGI:6760602
• Synonyms: Zic2cre^ERbroad
• Transgene: Tg(Zic2-cre/ERT2)1463Kln Location: unknown
• Alliance: Tg(Zic2-cre/ERT2)1463Kln page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Zic2-cre/ERT2)1463Kln expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Zic2 (MGI:106679)

• Mutation details: The transgene was generated by a bacterial recombineering technique to insert a cre/ERT2 expression cassette containing the polyadenylation site (polyA) from the SV40 early region into the exon 1 of the mouse Zic2 gene of a BAC clone RP23-158G6 (CHORI). Two transgenic founder lines were selected and established. Line 1463 shows broader cre activity in the spinal cord with some reporter staining seen in the dorsal root ganglion. (J:284540)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Zic2 (mouse) Summary of all recombinase alleles driven by Zic2. Comparative matrix view of recombinase activities Alliance mouse Zic2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:284540 Paixao S, et al., Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron. 2019 Nov 20;104(4):749-764.e6
• All: 1 reference(s)