Lect2^em1(cre)Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lect2^em1(cre)Smoc
• Name: leukocyte cell-derived chemotaxin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6760622
• Synonyms: Lect2-Cre, Lect2^{em1(2A-cre)Smoc}
• Gene: Lect2 Location: Chr13:56690277-56696315 bp, - strand Genetic Position: Chr13, 30.08 cM
• Alliance: Lect2^em1(cre)Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Lect2^em1(cre)Smoc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lect2 (MGI:1278342)

• Mutation details: A 2A-Cre expression cassette was knocked into the Lect2 gene stop codon site via CRISPR/Cas mediated recombination. (J:284498)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lect2 (mouse) Summary of all recombinase alleles driven by Lect2. Comparative matrix view of recombinase activities Alliance mouse Lect2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lect2 Mutation: 14 strains or lines available

References

• Original: J:284498 Xu M, et al., LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis. Cell. 2019 Sep 5;178(6):1478-1492.e20
• All: 1 reference(s)