Taar1^em2Ejc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Taar1^em2Ejc
• Name: trace amine-associated receptor 1; endonuclease-mediated mutation 2, Elissa Chesler
• MGI ID: MGI:6761316
• Gene: Taar1 Location: Chr10:23796304-23797302 bp, + strand Genetic Position: Chr10, 11.39 cM, cytoband A3
• Alliance: Taar1^em2Ejc page

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: This CRISPR/Cas9 mediated A to C point substitution in DBA/2J reverts the m1J spontaneous p.P77T mutation to the wild-type 77P amino acid and fully functional protein. (J:310042)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Taar1 Mutation: 34 strains or lines available

References

• Original: J:310042 Phillips TJ, et al., Confirmation of a causal Taar1Allelic variant in addiction-relevant methamphetamine behaviors. Front Psychiatry. 2021;12
• All: 1 reference(s)