Duox2^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Duox2^em1Btlr
• Name: dual oxidase 2; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6761324
• Synonyms: Duox2^indel
• Gene: Duox2 Location: Chr2:122109728-122128930 bp, - strand Genetic Position: Chr2, 60.61 cM
• Alliance: Duox2^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting produced an insertion mutation (chr2:122123150insA (GRCm39)) resulting in a frameshift and premature stop codon (Phe500Ilefs*7). (J:309727)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Duox2 Mutation: 73 strains or lines available

References

• Original: J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565
• All: 1 reference(s)