Slc17a6^{tm1.1(icre/ERT2)Bcgen}
Targeted Allele Detail

Summary

• Symbol: Slc17a6^{tm1.1(icre/ERT2)Bcgen}
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:6761378
• Synonyms: vGLUT2-iCreERT2
• Gene: Slc17a6 Location: Chr7:51271754-51320867 bp, + strand Genetic Position: Chr7, 32.78 cM, cytoband B4
• Alliance: Slc17a6^{tm1.1(icre/ERT2)Bcgen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243876
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Slc17a6^{tm1.1(icre/ERT2)Bcgen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc17a6 (MGI:2156052)

• Mutation details: A 2A-icre/ERT2 is introduced between the coding sequence of Slc17a6 Exon 12 and 3' UTR. Neo cassette flanked by frt sites was inserted within intron 11 to avoid disrupting poly(A) signal of Slc17a6. After homologous recombination in ES cells, the neo selection cassette was removed by Flp recombinase. (J:243876)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc17a6 (mouse) Summary of all recombinase alleles driven by Slc17a6. Comparative matrix view of recombinase activities Alliance mouse Slc17a6 gene page

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc17a6 Mutation: 60 strains or lines available

References

• Original: J:243876 Zhong H, et al., Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice. J Clin Invest. 2017 Jun 01;127(6):2295-2309
• All: 1 reference(s)