Tppp3^{tm2.1(cre/ERT2)Fan}
Targeted Allele Detail

Summary

• Symbol: Tppp3^{tm2.1(cre/ERT2)Fan}
• Name: tubulin polymerization-promoting protein family member 3; targeted mutation 2.1, Chen-Ming Fan
• MGI ID: MGI:6761419
• Synonyms: Tppp3^ECE, Tppp3^{P2A-ERT2CreERT2}
• Gene: Tppp3 Location: Chr8:106194125-106198158 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1
• Alliance: Tppp3^{tm2.1(cre/ERT2)Fan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282887
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv x C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tppp3^{tm2.1(cre/ERT2)Fan} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tppp3 (MGI:1915221)

• Mutation details: The CG(2A-ERT2-Cre-ERT2)-frt-neo-frt cassette was inserted upstream of the stop codon of the Tppp3 gene. No coding or 3UTR (untranslated region) sequences were deleted. Germline, flp mediated recombination removed the neo cassette. (J:282887)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tppp3 (mouse) Summary of all recombinase alleles driven by Tppp3. Comparative matrix view of recombinase activities Alliance mouse Tppp3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tppp3 Mutation: 20 strains or lines available

References

• Original: J:282887 Harvey T, et al., A Tppp3(+)Pdgfra(+) tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nat Cell Biol. 2019 Dec;21(12):1490-1503
• All: 2 reference(s)