Kl^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kl^em1Btlr
• Name: klotho; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6761423
• Synonyms: Kl^{p.Asn690LysfsTer28}
• Gene: Kl Location: Chr5:150876072-150917282 bp, + strand Genetic Position: Chr5, 89.77 cM, cytoband G3
• Alliance: Kl^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Not Specified, Single point mutation
• Mutation details: CRISPR-targeting produced an insertion/duplication mutation (chr5:150912321dupA (GRCm38)) resulting in a frameshift and premature stop codon (p.Asn690Lysfs*29). (J:309727)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kl Mutation: 53 strains or lines available

References

• Original: J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565
• All: 1 reference(s)