Tnfrsf11a^{tm1(icre)Wask}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11a^{tm1(icre)Wask}
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, Claudia Waskow
• MGI ID: MGI:6761745
• Synonyms: Rank-iCre
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^{tm1(icre)Wask} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267590
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tnfrsf11a^{tm1(icre)Wask} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tnfrsf11a (MGI:1314891)

• Mutation details: A cassette encoding an iCre-pA-FRT-PGK-Em7-neo-polyA-FRT was inserted into the first exon of the Tnfrsf11a1 gene by homologous recombination. The neo cassette was subsequently removed by crossing to Flpo mice. (J:267590)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tnfrsf11a (mouse) Summary of all recombinase alleles driven by Tnfrsf11a. Comparative matrix view of recombinase activities Alliance mouse Tnfrsf11a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

References

• Original: J:267590 Percin GI, et al., CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages. Nat Commun. 2018 Dec 11;9(1):5279
• All: 3 reference(s)