Sox10^tm1Ngan
Targeted Allele Detail

Summary

• Symbol: Sox10^tm1Ngan
• Name: SRY (sex determining region Y)-box 10; targeted mutation 1, Elly S W Ngan
• MGI ID: MGI:6762161
• Synonyms: Sox10^N, Sox10^NGFP, Sox10NGFP
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^tm1Ngan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The N terminal domain of Sox10 was replaced with the EGFP reporter gene via homologous recombination in ES cells. (J:301001)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:301001 Liu JA, et al., Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice. Gastroenterology. 2015 Dec;149(7):1837-1848.e5
• All: 3 reference(s)