Avpr1b^{tm2.1(cre)Wsy}
Targeted Allele Detail

Summary

• Symbol: Avpr1b^{tm2.1(cre)Wsy}
• Name: arginine vasopressin receptor 1B; targeted mutation 2.1, W Scott Young III
• MGI ID: MGI:6764454
• Synonyms: Avpr1b-Cre
• Gene: Avpr1b Location: Chr1:131526977-131539738 bp, + strand Genetic Position: Chr1, 57.09 cM, cytoband E4
• Alliance: Avpr1b^{tm2.1(cre)Wsy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310526
• Parent Cell Line: LC3 (ES Cell)
• Strain of Origin: (C57BL/6N x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Avpr1b^{tm2.1(cre)Wsy} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Avpr1b (MGI:1347010)

• Mutation details: The Cre-nuclear localization sequence and FRT flanked pgk-neo cassette was inserted to replace the coding region from the initiating codon in exon 1 of the mouse Avpr1b gene by homologous recombination in the ES cells. The chimeras generated from correctly targetted ES cells were crossed to the FLPe deleter to remove the pgk-neo cassette. The absence of Avpr1b mRNA in brain of homozygous mice was confirmed. (J:310526)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Avpr1b (mouse) Summary of all recombinase alleles driven by Avpr1b. Comparative matrix view of recombinase activities Alliance mouse Avpr1b gene page

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Avpr1b Mutation: 33 strains or lines available

References

• Original: J:310526 Williams Avram SK, et al., NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Front Behav Neurosci. 2019;13:218
• All: 2 reference(s)