Gper1^em1(cre)Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gper1^em1(cre)Smoc
• Name: G protein-coupled estrogen receptor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6764548
• Synonyms: Gper-Cre
• Gene: Gper1 Location: Chr5:139408906-139413555 bp, + strand Genetic Position: Chr5, 78.58 cM, cytoband G1
• Alliance: Gper1^em1(cre)Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Gper1^em1(cre)Smoc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gper1 (MGI:1924104)

• Using the CRISPR/Cas9 system the 2A-cre gene fragment was inserted at the Gper1 gene stop codon. (J:310221, J:311004)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gper1 (mouse) Summary of all recombinase alleles driven by Gper1. Comparative matrix view of recombinase activities Alliance mouse Gper1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gper1 Mutation: 30 strains or lines available

References

• Original: J:310221 Gao T, et al., G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch. J Neurosci. 2021 Sep 15;41(37):7727-7741
• All: 3 reference(s)