Oxt^{tm1.1(icre)Ksak}
Targeted Allele Detail

Summary

• Symbol: Oxt^{tm1.1(icre)Ksak}
• Name: oxytocin; targeted mutation 1.1, Kenji Sakimura
• MGI ID: MGI:6764587
• Synonyms: Oxt^cre, Oxt^{tm1.1(Cre)Ksak}
• Gene: Oxt Location: Chr2:130418093-130418974 bp, + strand Genetic Position: Chr2, 63.24 cM
• Alliance: Oxt^{tm1.1(icre)Ksak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310161
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Oxt^{tm1.1(icre)Ksak} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oxt (MGI:97453)

• Mutation details: The sequence of the self-processing furin-2A in front of the improved Cre (iCre) recombinase was inserted into the end of the coding sequence of the mouse Oxt gene. Frt flanked neo cassette was removed by crossing with the Actb-FLPe mouse line that expresses a Flp1 recombinase gene under the human ACTB promoter. (J:310161)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oxt (mouse) Summary of all recombinase alleles driven by Oxt. Comparative matrix view of recombinase activities Alliance mouse Oxt gene page

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oxt Mutation: 20 strains or lines available

References

• Original: J:310161 Fujima S, et al., CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. J Neurosci. 2021 May 19;41(20):4524-4535
• All: 1 reference(s)