Tbx3^em1(cre)Mhts
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbx3^em1(cre)Mhts
• Name: T-box 3; endonuclease-mediated mutation 1, Matthias H Tschop
• MGI ID: MGI:6764609
• Synonyms: Tbx3-Cre-Venus
• Gene: Tbx3 Location: Chr5:119808734-119822789 bp, + strand Genetic Position: Chr5, 60.34 cM
• Alliance: Tbx3^em1(cre)Mhts page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase, Reporter)
• Mutation: Insertion
• Tbx3^em1(cre)Mhts expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx3 (MGI:98495)

• Mutation details: Using CRISPR/Cas9 technology, coding sequences for 2A peptide bridges, Cre recombinase, 2A peptide bridges, Venus fluorescent protein, and bovine growth hormone polyadenylation signal were inserted into the stop codon of the Tbx3 locus. (J:310126)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx3 (mouse) Summary of all recombinase alleles driven by Tbx3. Comparative matrix view of recombinase activities Alliance mouse Tbx3 gene page

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx3 Mutation: 49 strains or lines available

References

• Original: J:310126 Quarta C, et al., Functional identity of hypothalamic melanocortin neurons depends on Tbx3. Nat Metab. 2019 Feb;1(2):222-235
• All: 1 reference(s)