Gipr^{em1(icre)Reim}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gipr^{em1(icre)Reim}
• Name: gastric inhibitory polypeptide receptor; endonuclease-mediated mutation 1, Frank Reimann
• MGI ID: MGI:6765436
• Synonyms: Gipr-Cre
• Gene: Gipr Location: Chr7:18889986-18900052 bp, - strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gipr^{em1(icre)Reim} page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Recombinase)
• Mutation: Insertion
• Gipr^{em1(icre)Reim} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gipr (MGI:1352753)

• Mutation details: UsingCRISPR/Cas9 technology, icre sequence was inserted into the start codon in exon2 of the mouse Gipr gene. (J:281552)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gipr (mouse) Summary of all recombinase alleles driven by Gipr. Comparative matrix view of recombinase activities Alliance mouse Gipr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gipr Mutation: 30 strains or lines available

References

• Original: J:281552 Adriaenssens AE, et al., Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metab. 2019 Nov 5;30(5):987-996.e6
• All: 3 reference(s)