Actrt1^em1Xwei
Endonuclease-mediated Allele Detail

Summary

• Symbol: Actrt1^em1Xwei
• Name: actin-related protein T1; endonuclease-mediated mutation 1, Xiaoli Wei
• MGI ID: MGI:6765445
• Gene: Actrt1 Location: ChrX:45417884-45419222 bp, + strand Genetic Position: ChrX, 24.54 cM, cytoband A3.1
• Alliance: Actrt1^em1Xwei page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNAs 5'-GACTAGGAACAACTGAGGTGC-3' and 5'-TGTGTCCCTCAGCATCCAAA-3' deleted a large fragment of the exon. (J:311034)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actrt1 Mutation: 3 strains or lines available

References

• Original: J:311034 Sha Y, et al., Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome. Front Cell Dev Biol. 2021;9:676246
• All: 1 reference(s)