Dct^{em1(cre/ERT2)Enis}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dct^{em1(cre/ERT2)Enis}
• Name: dopachrome tautomerase; endonuclease-mediated mutation 1, Emi K Nishimura
• MGI ID: MGI:6766471
• Synonyms: Dct-CreER^T2
• Gene: Dct Location: Chr14:118250202-118289656 bp, - strand Genetic Position: Chr14, 61.6 cM
• Alliance: Dct^{em1(cre/ERT2)Enis} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Dct^{em1(cre/ERT2)Enis} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dct (MGI:102563)

• Using CRISPR/Cas9 system, the cre/ERT2-polyA sequence was inserted into the mouse Dct gene locus. (J:311103)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dct (mouse) Summary of all recombinase alleles driven by Dct. Comparative matrix view of recombinase activities Alliance mouse Dct gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dct Mutation: 35 strains or lines available

References

• Original: J:311103 Eshiba S, et al., Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi. Cell Rep. 2021 Aug 3;36(5):109492
• All: 1 reference(s)