Spaca4^em1Pauli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Spaca4^em1Pauli
• Name: sperm acrosome associated 4; endonuclease-mediated mutation 1, Andrea Pauli
• MGI ID: MGI:6766529
• Synonyms: Spaca4^117del
• Gene: Spaca4 Location: Chr7:45374531-45375237 bp, - strand Genetic Position: Chr7, 29.46 cM
• Alliance: Spaca4^em1Pauli page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deletes 117 bp that produces a frameshift after amino acid 42. (J:311165)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spaca4 Mutation: 8 strains or lines available

References

• Original: J:311165 Fujihara Y, et al., The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2108777118
• All: 1 reference(s)