Aire^tm6.1Mmat
Targeted Allele Detail

Summary

• Symbol: Aire^tm6.1Mmat
• Name: autoimmune regulator; targeted mutation 6.1, Mitsuru Matsumoto
• MGI ID: MGI:6771348
• Synonyms: Aire/OVA
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^tm6.1Mmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252604
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to replace exon 1 with a membrane-bound form of ovalbumin consisting of a fusion protein made up of the first 118 residues of the human transferrin receptor (which includes the cytoplasmic tail and signal/anchor domain) linked to residues 139-385 of the chicken ovalbumin gene (OVA), followed by a loxP-flanked neo cassette. Cre-mediated recombination removed the floxed neo cassette. (J:252604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 53 strains or lines available

References

• Original: J:252604 Mouri Y, et al., Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen. J Immunol. 2017 Dec 15;199(12):3959-3971
• All: 1 reference(s)