Nbn^em7Jpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nbn^em7Jpt
• Name: nibrin; endonuclease-mediated mutation 7, John H Petrini
• MGI ID: MGI:6771585
• Synonyms: Nbs1^mid8
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^em7Jpt page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated genome-editing generated a 12 bp deletion (GAATTTCAAGAA) in the Mre11 interacting domain of exon 13, deleting KNFK residues in the LKNFKKFKK sequence of the Mre11 interacting domain . (J:251434)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:251434 Kim JH, et al., The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep. 2017 Jan 10;18(2):496-507
• All: 2 reference(s)