Entpd8^tm1Ktak
Targeted Allele Detail

Summary

• Symbol: Entpd8^tm1Ktak
• Name: ectonucleoside triphosphate diphosphohydrolase 8; targeted mutation 1, Kiyoshi Takeda
• MGI ID: MGI:6771668
• Gene: Entpd8 Location: Chr2:24970316-24975728 bp, + strand Genetic Position: Chr2, 16.97 cM, cytoband A3
• Alliance: Entpd8^tm1Ktak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311564
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 4 to 9 were replaced with a neo cassette via homologous recombination. (J:311564)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Entpd8 Mutation: 24 strains or lines available

References

• Original: J:311564 Tani H, et al., The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2100594118
• All: 1 reference(s)