Trpa1^em1(icre)Kob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trpa1^em1(icre)Kob
• Name: transient receptor potential cation channel, subfamily A, member 1; endonuclease-mediated mutation 1, Reiko Kobayakawa
• MGI ID: MGI:6781250
• Synonyms: Trpa1-Cre
• Gene: Trpa1 Location: Chr1:14942872-14989086 bp, - strand Genetic Position: Chr1, 4.5 cM
• Alliance: Trpa1^em1(icre)Kob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305273
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Trpa1^em1(icre)Kob expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trpa1 (MGI:3522699)

• Mutation details: Using CRISPR/Cas9-mediated genome editing in the ES cells, improved-Cre was inserted at the start codon of the endogenous mouse Trpa1 locus. (J:305273)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trpa1 (mouse) Summary of all recombinase alleles driven by Trpa1. Comparative matrix view of recombinase activities Alliance mouse Trpa1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpa1 Mutation: 94 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:305273 Matsuo T, et al., Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Nat Commun. 2021 Apr 6;12(1):2074
• All: 1 reference(s)