Tbr1^{tm1.1(cre/ERT2)Maoc}
Targeted Allele Detail

Summary

• Symbol: Tbr1^{tm1.1(cre/ERT2)Maoc}
• Name: T-box brain transcription factor 1; targeted mutation 1.1, Chai-An Mao
• MGI ID: MGI:6781269
• Synonyms: Tbr1-TauGFP-IRESCreERT2, Tbr1^{TauGFPIRESCreERT2}
• Gene: Tbr1 Location: Chr2:61633274-61644458 bp, + strand Genetic Position: Chr2, 35.56 cM
• Alliance: Tbr1^{tm1.1(cre/ERT2)Maoc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281028
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tbr1^{tm1.1(cre/ERT2)Maoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbr1 (MGI:107404)

• Mutation details: A Tbr1 (nonfunctional allele) were generated by inserting an Frt-PGKNeopA-Frt cassette and a synthetic TauGFP-IRESCreERT2 DNA fragment in the first exon behind the translation initiation codon ATG of Tbr1. The neo selection cassette was removed by FLP recombinase. (J:281028)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbr1 (mouse) Summary of all recombinase alleles driven by Tbr1. Comparative matrix view of recombinase activities Alliance mouse Tbr1 gene page

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbr1 Mutation: 38 strains or lines available

References

• Original: J:281028 Kiyama T, et al., Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 Apr 16;27(3):900-915.e5
• All: 2 reference(s)