Srsf5^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srsf5^em1Nju
• Name: serine and arginine-rich splicing factor 5; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6782384
• Gene: Srsf5 Location: Chr12:80992308-80997277 bp, + strand Genetic Position: Chr12, 37.2 cM, cytoband D2
• Alliance: Srsf5^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting removed exons 3 through 6. (J:311867)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf5 Mutation: 22 strains or lines available

References

• Original: J:311867 Zhang X, et al., Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium. iScience. 2021 Oct 22;24(10):103097
• All: 1 reference(s)