Hint1tm1b(EUCOMM)Wtsi
Targeted Allele Detail
|
Symbol: |
Hint1tm1b(EUCOMM)Wtsi |
Name: |
histidine triad nucleotide binding protein 1; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6782387 |
Gene: |
Hint1 Location: Chr11:54757209-54761327 bp, + strand Genetic Position: Chr11, 32.13 cM
|
Alliance: |
Hint1tm1b(EUCOMM)Wtsi page
|
IMPC: |
Hint1 gene page |
|
Mutant Cell Line: |
EPD0326_6_G01 |
Germline Transmission: |
Earliest citation of germline transmission:
J:311513
|
Parent Cell Line: |
JM8A1.N3 (ES Cell)
|
Strain of Origin: |
C57BL/6N-Atm1Brd
|
Project Collection: |
EUCOMM
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutations: |
|
Insertion, Intragenic deletion
Vector: L1L2_Bact_P
|
|
|
Mutation details: The L1L2_Bact_P cassette was inserted at position 54760244 of Chromosome 11 upstream of exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the exon 3 at position 54761593. Exons 2 and 3 are thus flanked by loxP sites. Cre mediated recombination without prior flp recombination created a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:311513)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Hint1 Mutation: |
25 strains or lines available
|
|
Original: |
J:311513 Sato M, et al., The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nat Commun. 2021 May 5;12(1):2529 |
All: |
1 reference(s) |
|