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Hint1tm1b(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Hint1tm1b(EUCOMM)Wtsi
Name: histidine triad nucleotide binding protein 1; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:6782387
Gene: Hint1  Location: Chr11:54757209-54761327 bp, + strand  Genetic Position: Chr11, 32.13 cM
Alliance: Hint1tm1b(EUCOMM)Wtsi page
IMPC: Hint1 gene page
Mutation
origin
Mutant Cell Line:  EPD0326_6_G01
Germline Transmission:  Earliest citation of germline transmission: J:311513
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 54760244 of Chromosome 11 upstream of exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the exon 3 at position 54761593. Exons 2 and 3 are thus flanked by loxP sites. Cre mediated recombination without prior flp recombination created a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:311513)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hint1 Mutation:  25 strains or lines available
References
Original:  J:311513 Sato M, et al., The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nat Commun. 2021 May 5;12(1):2529
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory