2500002B13Rik^{tm1(CAG-2500002B13Rik)Yo}
Targeted Allele Detail

Summary

• Symbol: 2500002B13Rik^{tm1(CAG-2500002B13Rik)Yo}
• Name: RIKEN cDNA 2500002B13 gene; targeted mutation 1, Yuichi Oike
• MGI ID: MGI:6782388
• Gene: 2500002B13Rik Location: Chr8:57940997-57963296 bp, + strand Genetic Position: Chr8, 29.86 cM
• Alliance: 2500002B13Rik^{tm1(CAG-2500002B13Rik)Yo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311513
• Parent Cell Line: KTPU8 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• 2500002B13Rik^{tm1(CAG-2500002B13Rik)Yo} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	2500002B13Rik (MGI:1925603)

• Mutation details: A construct containing a CAG promoter driving expression of 2500002B13Rik replaced the beta-geo gene in the 2500002B13Rik^{Gt(Ayu21-T167)Imeg} allele via recombinase mediated cassette exchange. Expression levels in the heart are elevated 40 times in heterozygous mice compared to wild-type controls. (J:311513)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any 2500002B13Rik Mutation: 7 strains or lines available

References

• Original: J:311513 Sato M, et al., The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nat Commun. 2021 May 5;12(1):2529
• All: 1 reference(s)