Mosmo^em1Rroh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mosmo^em1Rroh
• Name: modulator of smoothened; endonuclease-mediated mutation 1, Rajat Rohatgi
• MGI ID: MGI:6782393
• Gene: Mosmo Location: Chr7:120276841-120334077 bp, + strand Genetic Position: Chr7, 64.9 cM
• Alliance: Mosmo^em1Rroh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 386 bp deletion, including all of exon 1. (J:311933)

Expression

In Mice Carrying this Mutation:	65 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mosmo Mutation: 10 strains or lines available

References

• Original: J:311933 Kong JH, et al., Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development. 2021 Oct 1;148(19):dev199867
• All: 1 reference(s)