Klhl22^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klhl22^em1Cya
• Name: kelch-like 22; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6782847
• Synonyms: Klhl22^em1Cgen
• Gene: Klhl22 Location: Chr16:17577485-17611246 bp, + strand Genetic Position: Chr16, 11.01 cM
• Alliance: Klhl22^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR-targeting of exon 4 generated a 2,211 bp deletion and 2 bp insertion. (J:297538)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klhl22 Mutation: 34 strains or lines available

References

• Original: J:297538 Zhou XA, et al., KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28239-28250
• All: 1 reference(s)