Adamts10^em1Jku
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adamts10^em1Jku
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 10; endonuclease-mediated mutation 1, John Kuchtey
• MGI ID: MGI:6783437
• Synonyms: Adamts10^G661R
• Gene: Adamts10 Location: Chr17:33743178-33772756 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Adamts10^em1Jku page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced a glycine to arginine substitution at amino acid 661 (G661R). The G661R mutation was identified in a colony of Beagles with inherited primary open-angle glaucoma. (J:311879)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts10 Mutation: 43 strains or lines available

References

• Original: J:311879 Wu HJ, et al., Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10. Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):26
• All: 2 reference(s)