U2af1^tm1Mohi
Targeted Allele Detail

Summary

• Symbol: U2af1^tm1Mohi
• Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1; targeted mutation 1, M Golam Mohi
• MGI ID: MGI:6783443
• Synonyms: U2af1fl
• Gene: U2af1 Location: Chr17:31866055-31877866 bp, - strand Genetic Position: Chr17, 17.02 cM
• Alliance: U2af1^tm1Mohi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308564
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP upstream of exon 2 and a Rox-flanked neomycin resistance cassette with a 3' loxP site. (J:308564)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any U2af1 Mutation: 34 strains or lines available

References

• Original: J:308564 Dutta A, et al., U2af1 is required for survival and function of hematopoietic stem/progenitor cells. Leukemia. 2021 Aug;35(8):2382-2398
• All: 1 reference(s)