Irgm2^em2Myam
Endonuclease-mediated Allele Detail

Summary

• Symbol: Irgm2^em2Myam
• Name: immunity-related GTPase family M member 2; endonuclease-mediated mutation 2, Masahiro Yamamoto
• MGI ID: MGI:6784012
• Gene: Irgm2 Location: Chr11:58105803-58113609 bp, + strand Genetic Position: Chr11, 36.07 cM
• Alliance: Irgm2^em2Myam page

Mutation origin

• Strain of Origin: C57BL/6-Irgm1^em1Myam Igtp^em1Myam

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting induced a nucleotide change that resulted in the amino acid change of methionine to alanine at position 77 (M77A). (J:308470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irgm2 Mutation: 26 strains or lines available

Notes

This allele was targeted at the same time as two others to generate triple null mice: Irgm1^em1Myam Irgm2^em2Myam Igtp^em1Myam.

References

• Original: J:308470 Pradipta A, et al., Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization. Life Sci Alliance. 2021 Jul;4(7)
• All: 2 reference(s)