Tg(Prnp-UBQLN2)WT-hiHlp
Transgene Detail

Summary

• Symbol: Tg(Prnp-UBQLN2)WT-hiHlp
• Name: transgene insertion WT-hi, Henry L Paulson
• MGI ID: MGI:6784070
• Transgene: Tg(Prnp-UBQLN2)WT-hiHlp Location: unknown
• Alliance: Tg(Prnp-UBQLN2)WT-hiHlp page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains the following elements: the mouse prion protein gene promoter and exon 1, intron 1 and exon 2, sequence coding for a FLAG tag in-frame with the human UBQLN2 cDNA, and Prnp exon 3 and downstream sequence. This allele expresses high levels of transgenic peptide. (J:267076)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:267076 Sharkey LM, et al., Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10495-E10504
• All: 4 reference(s)