Ano3^tm1.1Lyj
Targeted Allele Detail

Summary

• Symbol: Ano3^tm1.1Lyj
• Name: anoctamin 3; targeted mutation 1.1, Lily Yeh Jan
• MGI ID: MGI:6790221
• Synonyms: Tmem16c Flox
• Gene: Ano3 Location: Chr2:110485546-110780854 bp, - strand Genetic Position: Chr2, 56.75 cM
• Alliance: Ano3^tm1.1Lyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A frt-neo-frt-loxP cassette was inserted in the 5' intronic region of exon 19 and a loxP site was inserted in the 3' intronic region of exon 20. Flp-mediated recombination removed the neomycin leaving exons 19 and 20 floxed. (J:310618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano3 Mutation: 77 strains or lines available

References

• Original: J:310618 Wang TA, et al., TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2023342118
• All: 1 reference(s)