Eif4b^tm1.2Smoc
Targeted Allele Detail

Summary

• Symbol: Eif4b^tm1.2Smoc
• Name: eukaryotic translation initiation factor 4B; targeted mutation 1.2, Shanghai Model Organisms Center
• MGI ID: MGI:6790236
• Synonyms: eIF4B^-
• Gene: Eif4b Location: Chr15:101982208-102005608 bp, + strand Genetic Position: Chr15, 57.26 cM
• Alliance: Eif4b^tm1.2Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were flanked by loxP sites and an FRT-flanked neomycin cassette was inserted downstream of exon 2. The neomycin cassette was removed via flp-mediated recombination. Exons 3 and 4 were deleted via cre-mediated recombination. (J:311140)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif4b Mutation: 47 strains or lines available

References

• Original: J:311140 Chen B, et al., Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity. Front Immunol. 2021;12:723885
• All: 1 reference(s)