Krt14^{tm1(cre/ERT2)Akli}
Targeted Allele Detail

Summary

• Symbol: Krt14^{tm1(cre/ERT2)Akli}
• Name: keratin 14; targeted mutation 1, Apostolos Klinakis
• MGI ID: MGI:6791378
• Synonyms: Krt14^CreERT2
• Gene: Krt14 Location: Chr11:100093988-100098336 bp, - strand Genetic Position: Chr11, 63.43 cM, cytoband D
• Alliance: Krt14^{tm1(cre/ERT2)Akli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239882
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Krt14^{tm1(cre/ERT2)Akli} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt14 (MGI:96688)

• Mutation details: A CreERT2-loxP-NeoR-loxP cassette was inserted into Kar14 initiation codon ATG via homologous recombination in ES cells. (J:239882)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt14 (mouse) Summary of all recombinase alleles driven by Krt14. Comparative matrix view of recombinase activities Alliance mouse Krt14 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt14 Mutation: 38 strains or lines available

References

• Original: J:239882 Papafotiou G, et al., KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis. Nat Commun. 2016 Jun 20;7:11914
• All: 1 reference(s)