Sp7^{tm1(icre)Bcgen}
Targeted Allele Detail

Summary

• Symbol: Sp7^{tm1(icre)Bcgen}
• Name: Sp7 transcription factor 7; targeted mutation 1, Biocytogen LLC
• MGI ID: MGI:6791387
• Synonyms: Osx-Cre, Sp7^tm1(iCre)Bcgen
• Gene: Sp7 Location: Chr15:102265038-102275498 bp, - strand Genetic Position: Chr15, 57.51 cM
• Alliance: Sp7^{tm1(icre)Bcgen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Sp7^{tm1(icre)Bcgen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sp7 (MGI:2153568)

• Mutation details: An F2A-iCre sequence cassette was placed between the coding sequence of exon 2 and 3UTR of the Sp7 gene in C57BL/6 ES cells. (J:308681)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sp7 (mouse) Summary of all recombinase alleles driven by Sp7. Comparative matrix view of recombinase activities Alliance mouse Sp7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp7 Mutation: 21 strains or lines available

References

• Original: J:240968 Liu J, et al., Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. Aging Cell. 2017 Apr;16(2):360-376
• All: 5 reference(s)