Muc13^tm1.1Mamg
Targeted Allele Detail

Summary

• Symbol: Muc13^tm1.1Mamg
• Name: mucin 13, epithelial transmembrane; targeted mutation 1.1 Michael McGuckin
• MGI ID: MGI:6810154
• Gene: Muc13 Location: Chr16:33614407-33640299 bp, + strand Genetic Position: Chr16, 24.21 cM
• Alliance: Muc13^tm1.1Mamg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:313870
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting cassette flanked exon 2 with a loxP site and a neomycin resistance cassette with a 3' loxP site. Cre-mediated recombination removed exon 2 and the selection cassette. (J:313870)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc13 Mutation: 21 strains or lines available

References

• Original: J:313870 Sheng YH, et al., The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut. 2011;60(12):1661-70
• All: 2 reference(s)