Tg(Thy1-SNCA*)#Ztzh
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA*)#Ztzh
• Name: transgene insertion, Zhentao Zhang
• MGI ID: MGI:6810775
• Synonyms: N103
• Transgene: Tg(Thy1-SNCA*)#Ztzh Location: unknown
• Alliance: Tg(Thy1-SNCA*)#Ztzh page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SNCA*)#Ztzh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  1-130 fragment of the human cDNA

• Mutation details: A fragment of the human alpha-synuclein 1-130 (an N-terminal fragment generated by aberrantly activated asparagine endopeptidase which cleaves alpha-synuclein at N103 and which is prone to aggregate and cause neurotoxicity) cDNA with its 5' UTR containing a Kozak enhance sequence before the initial codon and the 3' polyA tail is under the control of the neuron-specific Thy1 promoter. Western blot analysis confirmed expression of the 1-130 fragment in the brain and showed that the insoluble fragment is enriched in the olfactory bulb, cortex, striatum, substantia nigra, and pons. Insoluble alpha-synuclein phosphorylated at Ser129 is detected within all areas of the central nervous system. Two founders with high expression were used to generate lines. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:313970)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:313970 Tian Y, et al., Transgenic Mice Expressing Human alpha-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease. Front Aging Neurosci. 2021;13:760781
• All: 2 reference(s)