Sqor^em1.1Chji
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sqor^em1.1Chji
• Name: sulfide quinone oxidoreductase; endonuclease-mediated mutation 1.1, Jian Cheng
• MGI ID: MGI:6818628
• Synonyms: Sqr^-
• Gene: Sqor Location: Chr2:122607249-122651473 bp, + strand Genetic Position: Chr2, 60.67 cM, cytoband F2
• Alliance: Sqor^em1.1Chji page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology was used to flank exon 2 with loxP sites. Exon 2 was deleted via cre-mediated recombination. (J:314187)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqor Mutation: 33 strains or lines available

References

• Original: J:314187 Jia J, et al., SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. Sci Adv. 2020 Aug;6(35):eaaz5752
• All: 1 reference(s)