Slc16a13^em1Tac
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc16a13^em1Tac
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 13; endonuclease-mediated mutation 1, Taconic
• MGI ID: MGI:6825806
• Synonyms: Slc16a13 KO
• Gene: Slc16a13 Location: Chr11:70107615-70111890 bp, - strand Genetic Position: Chr11, 42.99 cM
• Alliance: Slc16a13^em1Tac page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Mutation details: The region upstream of the gene and intron 3 were targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 4218 bp deletion that includes exons 1-3. Transcript and protein expression experiments confirmed the lack of transcription from this allele. (J:309785)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc16a13 Mutation: 16 strains or lines available

References

• Original: J:309785 Schumann T, et al., Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol. 2021 Jul 1;4(1):826
• All: 1 reference(s)