Cachd1^em1Kjn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cachd1^em1Kjn
• Name: cache domain containing 1; endonuclease-mediated mutation 1, Kenneth R Johnson
• MGI ID: MGI:6827308
• Gene: Cachd1 Location: Chr4:100633870-100861741 bp, + strand Genetic Position: Chr4, 45.76 cM
• Alliance: Cachd1^em1Kjn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This 98 bp out-of-frame deletion and 1 bp G to A transition 4 bases later all within the protein coding sequence of exon1 was generated using CRISPR/cas9 mediated excision (J:314293)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cachd1 Mutation: 82 strains or lines available

References

• Original: J:314293 Tian C, et al., CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear. Hear Res. 2021 Sep 15;409:108327
• All: 1 reference(s)